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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GLP1R All Species: 22.42
Human Site: S431 Identified Species: 61.67
UniProt: P43220 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P43220 NP_002053.3 463 53060 S431 H L H I Q R D S S M K P L K C
Chimpanzee Pan troglodytes XP_527380 463 53011 S431 H L H I Q R D S S M K P L K C
Rhesus Macaque Macaca mulatta XP_001117104 474 54049 S442 H L H I Q R D S S M K P L K C
Dog Lupus familis XP_538899 447 51678 S415 H L H V Q R D S S M R P L K C
Cat Felis silvestris
Mouse Mus musculus O35659 489 55860 C431 H L N I Q R D C S M K P L K C
Rat Rattus norvegicus P32301 463 52858 S431 R L N I Q R D S S M K P L K C
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001129023 459 52529 S427 H L Y V Q R D S S M K P L K C
Frog Xenopus laevis O42602 415 47768 K384 R W H R W Q D K H S I R A R V
Zebra Danio Brachydanio rerio XP_693606 508 58211 R417 K D I D E E Y R H T H S Q T P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 85.8 86.3 N.A. 85.8 90.9 N.A. N.A. 76 29.5 47.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.7 87.9 90.9 N.A. 88.1 94.8 N.A. N.A. 86.8 49 60.4 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 86.6 N.A. 86.6 86.6 N.A. N.A. 86.6 13.3 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. N.A. 100 26.6 6.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % A
% Cys: 0 0 0 0 0 0 0 12 0 0 0 0 0 0 78 % C
% Asp: 0 12 0 12 0 0 89 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 12 12 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 67 0 56 0 0 0 0 0 23 0 12 0 0 0 0 % H
% Ile: 0 0 12 56 0 0 0 0 0 0 12 0 0 0 0 % I
% Lys: 12 0 0 0 0 0 0 12 0 0 67 0 0 78 0 % K
% Leu: 0 78 0 0 0 0 0 0 0 0 0 0 78 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 78 0 0 0 0 0 % M
% Asn: 0 0 23 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 78 0 0 12 % P
% Gln: 0 0 0 0 78 12 0 0 0 0 0 0 12 0 0 % Q
% Arg: 23 0 0 12 0 78 0 12 0 0 12 12 0 12 0 % R
% Ser: 0 0 0 0 0 0 0 67 78 12 0 12 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 12 0 0 0 12 0 % T
% Val: 0 0 0 23 0 0 0 0 0 0 0 0 0 0 12 % V
% Trp: 0 12 0 0 12 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 12 0 0 0 12 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _